Article
Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover.
PLoS biology - 1 Jan 2015
Kalapis Dorottya, Bezerra Ana R, Farkas Zoltán, Horvath Peter, Bódi Zoltán, Daraba Andreea, Szamecz Béla, Gut Ivo, Bayes Mónica, Santos Manuel A S, Pál Csaba
Abstract excerpt
Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was engineered to translate a codon ambiguously (mistranslation). It thereby overloads the protein quality-control pathways and disrupts cellular protein homeostasis. This...
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