Article

Anticodon sequence determines the impact of mistranslating tRNA <sup>Ala</sup> variants

2022-11-24

Abstract excerpt

Transfer RNAs (tRNAs) maintain translation fidelity through accurate charging by their cognate aminoacyl-tRNA synthetase and codon:anticodon base pairing with the mRNA at the ribosome. Mistranslation occurs when an amino acid not specified by the genetic message is incorporated into proteins and has applications in biotechnology, therapeutics and is relevant to disease. Since the alanyl-tRNA synthetase uniquely re...

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Literature Corpus work: 715caddb-186f-5e15-aa5a-3ce8aae42dbc
DOI: 10.1101/2022.11.23.517754

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