Article

Linking Codon- and Protein-Level Mutation Scores to Population Genetics Reveals Heterogeneous Selection Efficiency Across <i>Escherichia coli</i> Lineages

2026-03-18

Abstract excerpt

Quantifying the selective effects of individual mutations is essential to understand how their population-wise frequencies evolve under natural selection and genetic drift. Large genomic datasets provide a real-life experiment that we exploit to characterize the efficiency of selection across different mutations types and populations. Using Direct Coupling Analysis, a model from statistical physics, we derive prot...

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Literature Corpus work: 0c37c052-0449-5e1f-b58e-78b1b10acc09
DOI: 10.64898/2026.03.16.711857

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