Article
Measuring and detecting molecular adaptation in codon usage against nonsense errors during protein translation.
Genetics - 1 Dec 2009
Gilchrist Michael A, Shah Premal, Zaretzki Russell
Abstract excerpt
Codon usage bias (CUB) has been documented across a wide range of taxa and is the subject of numerous studies. While most explanations of CUB invoke some type of natural selection, most measures of CUB adaptation are heuristically defined. In contrast, we present a novel and mechanistic method for defining and contextualizing CUB adaptation to reduce the cost of nonsense errors during protein translation. Using a...
Topics
- Adaptation, Physiological
- Alleles
- Codon
- Codon, Nonsense
- Genome, Fungal
- Models, Genetic
- Protein Biosynthesis
- Saccharomyces cerevisiae