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Article

Mistranslating tRNA variants impact the proteome and phosphoproteome of Saccharomyces cerevisiae.

G3 (Bethesda, Md.) - 4 Feb 2026

Berg Matthew D, Chang Alexis T, Rodriguez-Mias Ricard A, Villén Judit

Abstract excerpt

Transfer RNAs (tRNAs) ensure accurate decoding of the genetic code. However, mutations in tRNAs can lead to misincorporation of an amino acid that differs from the genetic message in a process known as mistranslation. As mistranslating tRNAs modify how the genetic message is decoded, they have potential as therapeutic tools for diseases caused by nonsense and missense mutations. Despite this, they also produce...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41405719
DOI: 10.1093/g3journal/jkaf284
PMCID: PMC12869077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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