Article
The impact of mistranslation on phenotypic variability and fitness.
Evolution; international journal of organic evolution - 1 May 2021
Samhita Laasya, K Raval Parth, Stephenson Godwin, Thutupalli Shashi, Agashe Deepa
Abstract excerpt
Phenotypic variation is widespread in natural populations, and can significantly alter population ecology and evolution. Phenotypic variation often reflects underlying genetic variation, but also manifests via non-heritable mechanisms. For instance, translation errors result in about 10% of cellular proteins carrying altered sequences. Thus, proteome diversification arising from translation errors can potentially...
Topics
- Bacterial Proteins
- Biological Variation, Population
- Cell Proliferation
- Cell Survival
- Escherichia coli
- Evolution, Molecular
- Mutation
- Protein Biosynthesis