Article
A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans.
Genome biology - 1 Jan 2007
Gomes Ana C, Miranda Isabel, Silva Raquel M, Moura Gabriela R, Thomas Benjamin, Akoulitchev Alexandre, Santos Manuel A S
Abstract excerpt
BACKGROUND: Genetic code alterations have been reported in mitochondrial, prokaryotic, and eukaryotic cytoplasmic translation systems, but their evolution and how organisms cope and survive such dramatic genetic events are not understood. RESULTS: Here we used an unusual decoding of leucine CUG codons as serine in the main human fungal pathogen Candida albicans to elucidate the global impact of genetic code...
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