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Article

Phenotypic mutations contribute to protein diversity and shape protein evolution.

Protein science : a publication of the Protein Society - 1 Sept 2022

Romero Romero Maria Luisa, Landerer Cedric, Poehls Jonas, Toth-Petroczy Agnes

Abstract excerpt

Errors in DNA replication generate genetic mutations, while errors in transcription and translation lead to phenotypic mutations. Phenotypic mutations are orders of magnitude more frequent than genetic ones, yet they are less understood. Here, we review the types of phenotypic mutations, their quantifications, and their role in protein evolution and disease. The diversity generated by phenotypic mutation can...

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Identifiers

PMID: 36040266
DOI: 10.1002/pro.4397
PMCID: PMC9375231

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