Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice.

Nucleic acids research - 12 Apr 2024

Mononen Juho, Taipale Mari, Malinen Marjo, Velidendla Bharadwaja, Niskanen Einari, Levonen Anna-Liisa, Ruotsalainen Anna-Kaisa, Heikkinen Sami

Abstract excerpt

Most common genetic variants associated with disease are located in non-coding regions of the genome. One mechanism by which they function is through altering transcription factor (TF) binding. In this study, we explore how genetic variation is connected to differences in the regulatory landscape of livers from C57BL/6J and 129S1/SvImJ mice fed either chow or a high-fat diet. To identify sites where regulatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to CTCF gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to TF gene

Share to Genetic Variation

Share to Mice, Inbred C57BL

Share to Mice, Inbred Strains

Source

Open in PubMed Open full text

Identifiers

PMID: 38153160
DOI: 10.1093/nar/gkad1225
PMCID: PMC11014276

Genes

TF
CTCF
TCF7L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice.PMID 38153160Read ↗

Transcription factor occupancy is affected by genetic variation in the white adipose tissue of C57BL6/j and 129S1/SvImJ miceSemantic proximity Read ↗

Genetic variation shapes the chromatin accessibility landscape and transcriptional responses in mouse adipose tissue.Semantic proximity Read ↗

Tissue context determines the penetrance of regulatory DNA variation.Semantic proximity Read ↗

Tissue context determines the penetrance of regulatory DNA variationSemantic proximity Read ↗

Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function.Semantic proximity Read ↗

Genetic variation drives differences in obesity-related gene regulation.Semantic proximity Read ↗

Chromatin variation associated with liver metabolism is mediated by transposable elementsSemantic proximity Read ↗

Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains.Semantic proximity Read ↗

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolutionSemantic proximity Read ↗

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution.Semantic proximity Read ↗

Imputation of 3D genome structure by genetic-epigenetic interaction modeling in mice.Semantic proximity Read ↗

Causes and consequences of chromatin variation between inbred mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.