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Article

Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains.

Genes, brain, and behavior - 1 Aug 2008

Mulligan M K, Ponomarev I, Boehm S L, Owen J A, Levin P S, Berman A E, Blednov Y A, Crabbe J C, Williams R W, Miles M F, Bergeson S E

Abstract excerpt

C57BL/6 inbred mice have been widely used as research models; however, widespread demand has led to the creation of several B6 substrains with markedly different phenotypes. In this study, we report that two substrains of C57BL/6 mice, C57BL/6J (B6J) and C57BL/6NCrl (B6C), separated over 50 years ago at two different breeding facilities differ significantly in alcohol consumption and alcohol preference. The...

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PMID: 18397380
DOI: 10.1111/j.1601-183X.2008.00405.x

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