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Article

Genetic variation shapes the chromatin accessibility landscape and transcriptional responses in mouse adipose tissue.

PLoS genetics - 1 Jan 2026

Mononen Juho, Taipale Mari, Malinen Marjo, Levonen Anna-Liisa, Ruotsalainen Anna-Kaisa, Norton Luke, Heikkinen Sami

Abstract excerpt

Most of the disease associated genetic variants identified in genome wide association studies have been mapped to the non-coding regions of the genome. One of the leading mechanisms by which these variants are thought to affect disease susceptibility is by altering transcription factor (TF) binding. Even though inbred mouse strains have been commonly used to investigate polygenic diseases, less is known on how...

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Share to Adipose Tissue
Share to Adipose Tissue, White

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromatin Immunoprecipitation Sequencing

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Source

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Identifiers

PMID: 41544130
DOI: 10.1371/journal.pgen.1011716
PMCID: PMC12844536

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TF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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