Article

Tissue context determines the penetrance of regulatory DNA variation

2020-06-28

Abstract excerpt

Assessment of the functional consequences of disease-associated sequence variation at non-coding regulatory elements is complicated by their high degree of context sensitivity to both the local chromatin and nuclear environments. Allelic profiling of DNA accessibility across individuals has shown that only a select minority of sequence variation affects transcription factor (TF) occupancy, yet the low sequence div...

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Literature Corpus work: c8a359ca-7c07-5bc5-a83b-89d808c09e4c
DOI: 10.1101/2020.06.27.175422

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