Article

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution

2016-06-19

Abstract excerpt

Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor binding occupancy of three liver-specific transcription factors between crosses of two inbred mouse strains to elucidate the regulatory mechanisms underlying transcription factor binding variations in mammals. Our results highlight the pre-eminence of cis-acting...

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Literature Corpus work: bd6a161e-ae0b-5607-bc1e-760bdd5a79f5
DOI: 10.1101/059873

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