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Article

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution.

Nature communications - 23 Oct 2017

Wong Emily S, Schmitt Bianca M, Kazachenka Anastasiya, Thybert David, Redmond Aisling, Connor Frances, Rayner Tim F, Feig Christine, Ferguson-Smith Anne C, Marioni John C, Odom Duncan T, Flicek Paul

Abstract excerpt

Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor binding occupancy of three liver-specific transcription factors between crosses of two inbred mouse strains to elucidate the regulatory mechanisms underlying transcription factor binding variations in mammals. Our results highlight the pre-eminence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29061983
DOI: 10.1038/s41467-017-01037-x
PMCID: PMC5653656

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