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Article

Imputation of 3D genome structure by genetic-epigenetic interaction modeling in mice.

eLife - 26 Apr 2024

Kuffler Lauren, Skelly Daniel A, Czechanski Anne, Fortin Haley J, Munger Steven C, Baker Christopher L, Reinholdt Laura G, Carter Gregory W

Abstract excerpt

Gene expression is known to be affected by interactions between local genetic variation and DNA accessibility, with the latter organized into three-dimensional chromatin structures. Analyses of these interactions have previously been limited, obscuring their regulatory context, and the extent to which they occur throughout the genome. Here, we undertake a genome-scale analysis of these interactions in a...

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PMID: 38669177
DOI: 10.7554/eLife.88222
PMCID: PMC11052574

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