Article
Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function.
Cell - 14 Jun 2018
Link Verena M, Duttke Sascha H, Chun Hyun B, Holtman Inge R, Westin Emma, Hoeksema Marten A, Abe Yohei, Skola Dylan, Romanoski Casey E, Tao Jenhan, Fonseca Gregory J, Troutman Ty D, Spann Nathanael J, Strid Tobias, Sakai Mashito, Yu Miao, Hu Rong, Fang Rongxin, Metzler Dirk, Ren Bing, Glass Christopher K
Abstract excerpt
Non-coding genetic variation is a major driver of phenotypic diversity and allows the investigation of mechanisms that control gene expression. Here, we systematically investigated the effects of >50 million variations from five strains of mice on mRNA, nascent transcription, transcription start sites, and transcription factor binding in resting and activated macrophages. We observed substantial differences...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.