Article
Causes and consequences of chromatin variation between inbred mice.
PLoS genetics - 1 Jun 2013
Hosseini Mona, Goodstadt Leo, Hughes Jim R, Kowalczyk Monika S, de Gobbi Marco, Otto Georg W, Copley Richard R, Mott Richard, Higgs Douglas R, Flint Jonathan
Abstract excerpt
Variation at regulatory elements, identified through hypersensitivity to digestion by DNase I, is believed to contribute to variation in complex traits, but the extent and consequences of this variation are poorly characterized. Analysis of terminally differentiated erythroblasts in eight inbred strains of mice identified reproducible variation at approximately 6% of DNase I hypersensitive sites (DHS). Only 30%...
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