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Article

Tissue context determines the penetrance of regulatory DNA variation.

Nature communications - 14 May 2021

Halow Jessica M, Byron Rachel, Hogan Megan S, Ordoñez Raquel, Groudine Mark, Bender M A, Stamatoyannopoulos John A, Maurano Matthew T

Abstract excerpt

Functional assessment of disease-associated sequence variation at non-coding regulatory elements is complicated by their high degree of context sensitivity to both the local chromatin and nuclear environments. Allelic profiling of DNA accessibility across individuals has shown that only a select minority of sequence variation affects transcription factor (TF) occupancy, yet low sequence diversity in human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, 129 Strain

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Share to Regulatory Sequences, Nucleic Acid

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Identifiers

PMID: 33990600
DOI: 10.1038/s41467-021-23139-3
PMCID: PMC8121920

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