Gene point mutation information translation and detection: Leveraging single base extension and CRISPR/Cas12a.

Abstract excerpt

Gene point mutations play a significant role in the development of cancer. Therefore, developing a sensitive, specific, and universally applicable method for detecting gene point mutation is crucial for clinical diagnosis, prognosis, and cancer treatment. Recently, gene point mutation detection methods based on CRISPR/Cas12a detection have emerged. However, existing methods generally lack universality and...

Topics

• Humans
• Point Mutation
• Mutation
• CRISPR-Cas Systems
• ErbB Receptors
• Lung Neoplasms
• Protein Kinase Inhibitors
• Biosensing Techniques