Article
High-Fidelity Identification of Single Nucleotide Polymorphism by Type V CRISPR Systems.
ACS sensors - 22 Dec 2023
He Yawen, Shao Shengjie, Chen Juhong
Abstract excerpt
Accurate and sensitive detection of single nucleotide polymorphism (SNP) holds significant clinical implications, especially in the field of cancer diagnosis. Leveraging its high accuracy and programmability, the CRISPR system emerges as a promising platform for advancing the identification of SNPs. In this study, we compared two type V CRISPR/Cas systems (Cas12a and Cas14a) for the identification of...
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