Article
CUT-PCR: CRISPR-mediated, ultrasensitive detection of target DNA using PCR.
Oncogene - 7 Dec 2017
Lee S H, Yu J, Hwang G-H, Kim S, Kim H S, Ye S, Kim K, Park J, Park D Y, Cho Y-K, Kim J-S, Bae S
Abstract excerpt
Circulating tumor DNA (ctDNA) has emerged as a tumor-specific biomarker for the early detection of various cancers. To date, several techniques have been devised to enrich the extremely small amounts of ctDNA present in plasma, but they are still insufficient for cancer diagnosis, especially at the early stage. Here, we developed a novel method, CUT (CRISPR-mediated, Ultrasensitive detection of Target DNA)-PCR,...
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