Article
CRISPR/Cas9 mediated triple signal amplification platform for high selective and sensitive detection of single base mutations.
Analytica chimica acta - 16 Oct 2022
Zhou Mengyang, Wang Haoyu, Li Chao, Yan Chao, Qin Panzhu, Huang Lin
Abstract excerpt
Single base mutations detection is crucial for the diagnosis and treatment of cancer. However, the current methods with poor selectivity and sensitivity required large instruments, which are difficult to meet clinical demands. Herein, we develop a CRISPR/Cas9 based visual colorimetric platform to specifically detect all single base mutations. In this strategy, the Recombinase Polymerase Amplification (RPA) was...
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