Article
New applications of CRISPR/Cas9 system on mutant DNA detection.
Gene - 30 Jan 2018
Jia Chenqiang, Huai Cong, Ding Jiaqi, Hu Lingna, Su Bo, Chen Hongyan, Lu Daru
Abstract excerpt
The detection of mutant DNA is critical for precision medicine, but low-frequency DNA mutation is very hard to be determined. CRISPR/Cas9 is a robust tool for in vivo gene editing, and shows the potential for precise in vitro DNA cleavage. Here we developed a DNA mutation detection system based on CRISPR/Cas9 that can detect gene mutation efficiently even in a low-frequency condition. The system of CRISPR/Cas9...
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