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Article

A CRISPR/Cas9-regulated dual-ring topological allosteric probe for detection of the EGFR L858R resistance mutation in CTCs.

Analytical methods : advancing methods and applications - 5 Mar 2026

Wang Chenxing, Li Dandan, Yu Rongjun, Xue Jianjiang, Xie Wei, Zhang Qiongyuan, Gui Xiao, Wang Lilin, Guo Sihan, Xie Yu, Jiang Yu, Liu Gang, Wu Jiangling

Abstract excerpt

A single-nucleotide polymorphism (SNP) is a point mutation occurring at a defined genomic locus, and its precise and rapid detection in circulating tumor cells (CTCs) is essential for early diagnosis and therapeutic monitoring of non-small cell lung cancer (NSCLC). In this study, a CRISPR/Cas9-regulated dual-ring topological allosteric probe was developed for ultrasensitive and specific detection of the EGFR...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41685943
DOI: 10.1039/d5ay02124c

Genes

EGFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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