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A CRISPR Test for Rapidly and Sensitively Detecting Circulating EGFR Mutations

19 Feb 2020

Abstract excerpt

The detection of EGFR mutations in circulating cell-free DNA can enable personalized therapy for cancer. The current techniques for detecting circulating EGFR mutations are expensive and time-consuming with moderate sensitivity. Emerging CRISPR is revolutionizing medical diagnostics and showing a great promise for nucleic acid detection. This study aims to develop CRISPR-Cas12a as a simple test to sensitively...

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PMID: 32093010
DOI: 10.3390/diagnostics10020114

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