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Article

Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.

Endocrinology - 23 Dec 2023

Behrmann Abraham, Zhong Dalian, Li Li, Xie Shangkui, Mead Megan, Sabaeifard Parastoo, Goodarzi Mohammad, Lemoff Andrew, Kozlitina Julia, Towler Dwight A

Abstract excerpt

Wnt16 is expressed in bone and arteries, and maintains bone mass in mice and humans, but its role in cardiovascular physiology is unknown. We show that Wnt16 protein accumulates in murine and human vascular smooth muscle (VSM). WNT16 genotypes that convey risk for bone frailty also convey risk for cardiovascular events in the Dallas Heart Study. Murine Wnt16 deficiency, which causes postnatal bone loss, also...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to RNA, Small Interfering

Share to Transcription Factors

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 38123514
DOI: 10.1210/endocr/bqad192
PMCID: PMC10765280

Genes

LDLR
WNT16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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