Article

<i>wnt16</i> regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome

2021-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Bone and muscle interact through developmental, mechanical, paracrine, and autocrine signals. Genetic variants at the CPED1-WNT16 locus are dually associated with bone- and muscle-related traits. While Wnt16 is necessary for bone mass and strength, this fails to explain pleiotropy at this locus. Here, we show wnt16 is required for spine and muscle morphogenesis in zebrafish. In embryos, wnt1...

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Literature Corpus work: 9d1f40e3-2b12-58de-a3c5-584e7f2e14aa
DOI: 10.1101/2021.08.12.456120

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