Article

VGLL4 promotes thoracic aortic aneurysm and dissection by disrupting extracellular matrix homeostasis via WISP1-mediated TIMP3/MMP9 imbalance

2026-08-30

Abstract excerpt

Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening disease characterized by progressive medial degeneration, impaired mechanical integrity, and extracellular matrix (ECM) degradation. However, no pharmacological therapy has been proven to halt aneurysm progression or prevent dissection or rupture. Vascular smooth muscle cells (VSMCs) are vital for maintaining medial architecture by sensing and re...

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Literature Corpus work: a326263d-9c1f-5780-a19d-a25f864de77d
DOI: 10.64898/2026.08.26.747433

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