Article
PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition.
Nature cardiovascular research - 1 Nov 2025
Tan Josephine M E, Cheng Lan, Calhoun Ryan P, Weller Angela H, Drareni Karima, Fong Skylar, Barbara Eirlys, Lim Hee-Woong, Xue Chenyi, Winter Hanna, Auguste Gaëlle, Miller Clint L, Reilly Muredach P, Maegdefessel Lars, Lutgens Esther, Seale Patrick
Abstract excerpt
Vascular smooth muscle cells (SMCs) undergo phenotype switching to acquire various fates in response to pathological stimuli. Among these, 'synthetic' SMCs-defined by migration, proliferation and extracellular matrix production-accumulate in atherosclerotic lesions and contribute to fibrous cap formation. The mechanisms driving this synthetic transition remain unclear. Here we identify PRDM16, a gene linked to...
Read the complete abstract on PubMedTopics
- Animals
- Myocytes, Smooth Muscle
- Plaque, Atherosclerotic
- Muscle, Smooth, Vascular
- Transcription Factors