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Article

Coronary artery disease risk gene PRDM16 regulates smooth muscle homeostasis.

Journal of molecular and cellular cardiology - 1 Apr 2026

Dong Kunzhe, Zuo Yingbing, Yao Yali, He Xiangqin, Hu Guoqing, Peng Xiaoping, Zhou Jiliang

Abstract excerpt

OBJECTIVE: Vascular smooth muscle cells (VSMCs) are the primary contractile component of blood vessels and can undergo phenotypic switching from a contractile to a synthetic phenotype in vascular diseases such as coronary artery disease (CAD) and restenosis. This process leads to decreased expression of SMC lineage genes and increased proliferative, migratory and secretory abilities that drive disease...

Topics

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Coronary Artery Disease
DNA-Binding Proteins
Gene Expression Regulation
Homeostasis
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Smooth, Vascular

Myocytes, Smooth Muscle

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Identifiers

PMID: 41667033
DOI: 10.1016/j.yjmcc.2026.02.002
PMCID: PMC13215035

Genes

PRDM16
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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