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Article

The transmembrane protein TMEM16A is required for normal development of the murine trachea.

Developmental biology - 1 Sept 2008

Rock Jason R, Futtner Christopher R, Harfe Brian D

Abstract excerpt

Pathological collapsibility of the upper airways, caused by many different genetic and environmental insults, is known as tracheomalacia in humans. We determined that Tmem16a, a member of an evolutionarily conserved family of predicted transmembrane proteins, is expressed in the developing trachea. We report that all mice homozygous for a null allele of Tmem16a died within one month of birth and exhibited severe...

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Identifiers

PMID: 18585372
DOI: 10.1016/j.ydbio.2008.06.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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