Article
An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm.
Nature communications - 8 Mar 2018
Lino Cardenas Christian L, Kessinger Chase W, Cheng Yisha, MacDonald Carolyn, MacGillivray Thomas, Ghoshhajra Brian, Huleihel Luai, Nuri Saifar, Yeri Ashish S, Jaffer Farouc A, Kaminski Naftali, Ellinor Patrick, Weintraub Neal L, Malhotra Rajeev, Isselbacher Eric M, Lindsay Mark E
Abstract excerpt
Thoracic aortic aneurysm (TAA) has been associated with mutations affecting members of the TGF-β signaling pathway, or components and regulators of the vascular smooth muscle cell (VSMC) actomyosin cytoskeleton. Although both clinical groups present similar phenotypes, the existence of potential common mechanisms of pathogenesis remain obscure. Here we show that mutations affecting TGF-β signaling and VSMC...
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