Article
Transcription regulation by TBX18 in smooth muscle cells is essential for normal aortic development and homeostasis.
Cardiovascular research - 9 Dec 2025
Mukherjee Debanjan, Larcher Veronica, Winter Hanna, Sachs Nadja, Andriani Francesca, Chiesa Mattia, Perrucci Gianluca L, Rega Sara, Günther Stefan, Kuenne Carsten, Martin Jody C, Gu Yusu, Pelisek Jaroslav, Fischer Ariane, Peruzzo Sofia, Pizzo Emanuele, Peterson Kirk L, Dimmeler Stefanie, Maegdefessel Lars, Cattaneo Paola, Evans Sylvia M, Guimarães-Camboa Nuno
Abstract excerpt
AIMS: This study investigated whether TBX18, a transcription factor known for its critical roles in cardiovascular and urogenital development, but never previously studied in the context of the aorta, contributes to the normal development and homeostasis of this major artery. METHODS AND RESULTS: Histological analyses revealed Tbx18 expression in smooth muscle cells (SMCs) of the adult and embryonic aorta....
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