Article
Prdm16 Amplifies Notch Signaling and Suppresses Venous Lineage Specification to Prevent Arteriovenous Malformations During Vascular Development.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2026
Van Wauwe Jore, Janarthanan Pavithra, Craps Sander, Kc Ashmita, Asuncion Lisabel, Vrancaert Pieter, Kemps Hannelore, Daems Margo, Finck Christopher, Wright Shane, Müller Christian, Leigh Nicholas D, Renné Thomas, Ola Roxana, Panáková Daniela, Frye Maike, MacRae Calum A, Luttun Aernout, Beerens Manu
Abstract excerpt
BACKGROUND: TF (transcription factor) Prdm16 (positive regulatory domain-containing protein 16) regulates hematopoietic and neuronal stem cell homeostasis, adipose differentiation, and cardiac development. Its role in the circulatory system extends beyond the heart, as Prdm16 loss in arterial endothelial cells (ECs) impairs arterial reperfusion of ischemic mouse limbs due to endothelial dysfunction, and PRDM16...
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