Article
Loss of Wnt16 Leads to Skeletal Deformities and Downregulation of Bone Developmental Pathway in Zebrafish.
International journal of molecular sciences - 22 Jun 2021
Qu Xiaochao, Liao Mei, Liu Weiwei, Cai Yisheng, Yi Qiaorong, Long Jianmei, Tan Lijun, Deng Yun, Deng Hongwen, Chen Xiangding
Abstract excerpt
Wingless-type MMTV integration site family, member 16 (wnt16), is a wnt ligand that participates in the regulation of vertebrate skeletal development. Studies have shown that wnt16 can regulate bone metabolism, but its molecular mechanism remains largely undefined. We obtained the wnt16-/- zebrafish model using the CRISPR-Cas9-mediated gene knockout screen with 11 bp deletion in wnt16, which led to the premature...
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