Article
Variation in the Kozak sequence of WNT16 results in an increased translation and is associated with osteoporosis related parameters.
Bone - 1 Feb 2014
Hendrickx Gretl, Boudin Eveline, Fijałkowski Igor, Nielsen Torben Leo, Andersen Marianne, Brixen Kim, Van Hul Wim
Abstract excerpt
The importance of WNT16 in the regulation of bone metabolism was recently confirmed by several genome-wide association studies and by a Wnt16 (Wnt16(-/-)) knockout mouse model. The aim of this study was thus to replicate and further elucidate the effect of common genetic variation in WNT16 on osteoporosis related parameters. Hereto, we performed a WNT16 candidate gene association study in a population of healthy...
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