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Intrinsically disordered regions of the Msn2 transcription factor encode multiple functions using interwoven sequence grammars.

Nucleic acids research - 21 Mar 2024

Mindel Vladimir, Brodsky Sagie, Cohen Aileen, Manadre Wajd, Jonas Felix, Carmi Miri, Barkai Naama

Abstract excerpt

Intrinsically disordered regions (IDRs) are abundant in eukaryotic proteins, but their sequence-function relationship remains poorly understood. IDRs of transcription factors (TFs) can direct promoter selection and recruit coactivators, as shown for the budding yeast TF Msn2. To examine how IDRs encode both these functions, we compared genomic binding specificity, coactivator recruitment, and gene induction...

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Identifiers

PMID: 38109289
DOI: 10.1093/nar/gkad1191
PMCID: PMC10954448

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TF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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