Article

TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins

2025-10-20

Abstract excerpt

Transcription factors (TFs) bind specific DNA sequences to control gene expression. Modulating TF activity is of considerable therapeutic interest but very few TFs have been successfully drugged. TF DNA-binding interfaces are large and most TFs have no known allosteric ligands or allosteric sites. Here, we introduce TF-MAPs, a scalable and general platform to chart complete functional maps of sequence-specific DNA...

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Literature Corpus work: 150b9211-2a0c-50da-997a-0dee8ba6dcbf
DOI: 10.1101/2025.10.20.683418

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