Article

DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2

2023-06-16

Abstract excerpt

More than 1600 human transcription factors orchestrate the transcriptional machinery to control gene expression and cell fate. Their function is conveyed through intrinsically disordered regions (IDRs) containing activation or repression domains but lacking quantitative structural ensemble models prevents their mechanistic decoding. Here we integrate single-molecule FRET and NMR spectroscopy with molecular simulat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ddb3c549-b195-5cda-b5f7-38f620a9ca3e
DOI: 10.1101/2023.06.16.545083

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2DOI 10.1101/2023.06.16.545083Read

PolyA/polyQ-mediated conformational rewiring regulates DNA engagement and drives aggregation in the neuronal transcription factor Ascl1Semantic proximity Read

The intrinsically disordered transcriptional activation domain of CIITA is functionally tuneable by single substitutions: An exception or a new paradigm?Semantic proximity Read

TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteinsSemantic proximity Read

Disordered but Different: Functional and Evolutionary Divergence of Transcription Factor Intrinsically Disordered RegionsSemantic proximity Read

Classification of Human Transcription Factors Based on Their Effector Domains via Unsupervised LearningSemantic proximity Read

An activity-specificity trade-off encoded in human transcription factors.Semantic proximity Read

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activitySemantic proximity Read

Nucleosome Engagement Regulates RORγt Structure and DynamicsSemantic proximity Read

A ubiquitous disordered protein interaction module orchestrates transcription elongation.Semantic proximity Read

DNA flexibility regulates transcription factor binding to nucleosomesSemantic proximity Read

Structural elements facilitate extreme long-range gene regulation at a human disease locusSemantic proximity Read

Tethered-hopping model for protein-DNA binding and unbinding based on Sox2-Oct1-Hoxb1 ternary complex simulations.Semantic proximity Read