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Article

Disordered sequences of transcription factors regulate genomic binding by integrating diverse sequence grammars and interaction types.

Nucleic acids research - 27 Aug 2024

Hurieva Bohdana, Kumar Divya Krishna, Morag Rotem, Lupo Offir, Carmi Miri, Barkai Naama, Jonas Felix

Abstract excerpt

Intrinsically disordered regions (IDRs) guide transcription factors (TFs) to their genomic binding sites, raising the question of how structure-lacking regions encode for complex binding patterns. We investigated this using the TF Gln3, revealing sets of IDR-embedded determinants that direct Gln3 binding to respective groups of functionally related promoters, and enable tuning binding preferences between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38908024
DOI: 10.1093/nar/gkae521
PMCID: PMC11347154

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TF

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