Article

Molecular grammars of intrinsically disordered regions that span the human proteome

2025-02-28

Abstract excerpt

Intrinsically disordered regions (IDRs) of proteins are defined by functionally relevant molecular grammars. This refers to IDR-specific non-random amino acid compositions and non-random patterning of distinct pairs of amino acid types. Here, we introduce GIN (Grammars Inferred using NARDINI+) as a resource, which we have used to extract the molecular grammars of all human IDRs and classified them into thirty dist...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 61875587-b941-5fb3-93ba-9bccc3ddf8d0
DOI: 10.1101/2025.02.27.640591

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular grammars of intrinsically disordered regions that span the human proteomeDOI 10.1101/2025.02.27.640591Read

How mutations of intrinsically disordered protein regions can drive cancerSemantic proximity Read

Disentangling the CHAOS of intrinsic disorder in human proteinsSemantic proximity Read

Disordered but Different: Functional and Evolutionary Divergence of Transcription Factor Intrinsically Disordered RegionsSemantic proximity Read

Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies.Semantic proximity Read

Intrinsically disordered proteins and structured proteins with intrinsically disordered regions have different functional roles in the cellSemantic proximity Read

A Functional Map of the Human Intrinsically Disordered ProteomeSemantic proximity Read

Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions.Semantic proximity Read

An Atlas of Short Linear Motif-Mediated Human Protein-Protein InteractionsSemantic proximity Read

Ancient evolutionary origin of intrinsically disordered cancer risk regionsSemantic proximity Read

Evolutionary forces on different flavors of intrinsic disorder in the human proteomeSemantic proximity Read

Distinct types of disorder in the human proteome: functional implications for alternative splicing.Semantic proximity Read

Unfoldomics of human genetic diseases: illustrative examples of ordered and intrinsically disordered members of the human diseasome.Semantic proximity Read