Article

Beyond motif recognition: Specificity of human transcription factors in yeast

2026-04-29

Abstract excerpt

Transcription factors (TFs) bind DNA through sequence-specific DNA-binding domains (DBDs), yet genome-wide analyses show that TFs occupy only a small fraction of their motif occurrences. This raises the question of how TFs distinguish specific targets from the many potential sites in the genome. To investigate determinants of binding specificity beyond the cognate motif and cofactor influences, we measured the bin...

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Literature Corpus work: 511fe2e7-6a07-5752-b08e-bc760b0629be
DOI: 10.64898/2026.04.27.721015

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