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Article

The molecular grammar of protein disorder guiding genome-binding locations.

Nucleic acids research - 9 Jun 2023

Jonas Felix, Carmi Miri, Krupkin Beniamin, Steinberger Joseph, Brodsky Sagie, Jana Tamar, Barkai Naama

Abstract excerpt

Intrinsically disordered regions (IDRs) direct transcription factors (TFs) towards selected genomic occurrences of their binding motif, as exemplified by budding yeast's Msn2. However, the sequence basis of IDR-directed TF binding selectivity remains unknown. To reveal this sequence grammar, we analyze the genomic localizations of >100 designed IDR mutants, each carrying up to 122 mutations within this 567-AA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36938874
DOI: 10.1093/nar/gkad184
PMCID: PMC10250222

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