Article

The intrinsically disordered transcriptional activation domain of CIITA is functionally tuneable by single substitutions: An exception or a new paradigm?

2023-11-02

Abstract excerpt

<h4>ABSTRACT</h4> During protein evolution, some amino acid substitutions modulate protein function (“tuneability”). In most proteins, the tuneable range is wide and can be sampled by a set of protein variants that each contains multiple amino acid substitutions. In other proteins, the full tuneable range can be accessed by a set of variants that each contains a single substitution. Indeed, in some globular prote...

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Literature Corpus work: a82289a9-bf69-5526-b6cb-529968fafa24
DOI: 10.1101/2023.11.02.565367

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