Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An activity-specificity trade-off encoded in human transcription factors.

Nature cell biology - 1 Aug 2024

Naderi Julian, Magalhaes Alexandre P, Kibar Gözde, Stik Gregoire, Zhang Yaotian, Mackowiak Sebastian D, Wieler Hannah M, Rossi Francesca, Buschow Rene, Christou-Kent Marie, Alcoverro-Bertran Marc, Graf Thomas, Vingron Martin, Hnisz Denes

Abstract excerpt

Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is unclear. Here we provide evidence for an evolutionary trade-off between the activity and specificity in human TFs encoded as submaximal dispersion of aromatic residues in their intrinsically disordered protein regions. We identified approximately 500 human TFs that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Transcription Factors
Share to Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Reprogramming

Share to Gene Expression Regulation

Share to HEK293 Cells

Share to Intrinsically Disordered Proteins

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 38969762
DOI: 10.1038/s41556-024-01411-0
PMCID: PMC11321997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An activity-specificity trade-off encoded in human transcription factors.PMID 38969762Read ↗

Disordered but Different: Functional and Evolutionary Divergence of Transcription Factor Intrinsically Disordered RegionsSemantic proximity Read ↗

The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease DevelopmentSemantic proximity Read ↗

Unblending of Transcriptional Condensates in Human Repeat Expansion Disease.Semantic proximity Read ↗

The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease Development.Semantic proximity Read ↗

Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations.Semantic proximity Read ↗

The intrinsically disordered transcriptional activation domain of CIITA is functionally tuneable by single substitutions: An exception or a new paradigm?Semantic proximity Read ↗

Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcriptionSemantic proximity Read ↗

Spatially clustered pattern of transcription factor binding reveals phase-separated transcriptional condensates at super-enhancersSemantic proximity Read ↗

Merging Established Mechanisms with New Insights: Condensates, Hubs, and the Regulation of RNA Polymerase II Transcription.Semantic proximity Read ↗

Classification of Human Transcription Factors Based on Their Effector Domains via Unsupervised LearningSemantic proximity Read ↗

DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2Semantic proximity Read ↗

Activity-dependent degradation of Kv4.2 contributes to synaptic plasticity and behavior in Angelman syndrome model miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.