Article

Classification of Human Transcription Factors Based on Their Effector Domains via Unsupervised Learning

2025-10-27

Abstract excerpt

<h4>SUMMARY</h4> TFs combine DBDs, which anchor them to DNA, with EDs that regulate transcription through activation or repression, yet the sequence logic linking ED composition to function remains unclear. Here, we systematically define proxy regions —disordered segments adjacent to DBDs—to enable quantitative analysis of ED-like sequences across the human TF repertoire. Using a biophysically interpretable 22-f...

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Literature Corpus work: 422a584d-02a7-570c-8ae6-a1ec66023fe9
DOI: 10.1101/2025.10.26.684687

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