Article

Disordered but Different: Functional and Evolutionary Divergence of Transcription Factor Intrinsically Disordered Regions

2026-01-28

Abstract excerpt

Intrinsically disordered regions (IDRs) of proteins play key roles in multivalent interactions and the formation of biomolecular condensates. IDRs are widespread across the human proteome but are significantly enriched in transcription factor (TF) activation domains. However, it remains unclear why TF activation domains are enriched for IDRs and whether these regions are fundamentally distinct from IDRs in other p...

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Literature Corpus work: ccd9bf5a-08cc-5748-adea-c5546ea6ddd0
DOI: 10.64898/2026.01.27.700206

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