Article
A ubiquitous disordered protein interaction module orchestrates transcription elongation.
Science (New York, N.Y.) - 26 Nov 2021
Cermakova Katerina, Demeulemeester Jonas, Lux Vanda, Nedomova Monika, Goldman Seth R, Smith Eric A, Srb Pavel, Hexnerova Rozalie, Fabry Milan, Madlikova Marcela, Horejsi Magdalena, De Rijck Jan, Debyser Zeger, Adelman Karen, Hodges H Courtney, Veverka Vaclav
Abstract excerpt
During eukaryotic transcription elongation, RNA polymerase II (RNAP2) is regulated by a chorus of factors. Here, we identified a common binary interaction module consisting of TFIIS N-terminal domains (TNDs) and natively unstructured TND-interacting motifs (TIMs). This module was conserved among the elongation machinery and linked complexes including transcription factor TFIIS, Mediator, super elongation complex,...
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