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Article

Human RAD52 stimulates the RAD51-mediated homology search

11 Dec 2023

Abstract excerpt

Homologous recombination (HR) is a DNA repair mechanism of double-strand breaks and blocked replication forks, involving a process of homology search leading to the formation of synaptic intermediates that are regulated to ensure genome integrity. RAD51 recombinase plays a central role in this mechanism, supported by its RAD52 and BRCA2 partners. If the mediator function of BRCA2 to load RAD51 on RPA-ssDNA is...

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PMID: 38081641
DOI: 10.26508/lsa.202201751

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