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Article

Molecular Pathways: Understanding the Role of Rad52 in Homologous Recombination for Therapeutic Advancement

17 Oct 2012

Abstract excerpt

The Rad52 protein was largely ignored in humans and other mammals when the mouse knockout revealed a largely "no-effect" phenotype. However, using synthetic lethal approaches to investigate context-dependent function, new studies have shown that Rad52 plays a key survival role in cells lacking the function of the breast cancer type 1 susceptibility protein (BRCA1)-BRCA2 pathway of homologous recombination....

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Identifiers

PMID: 23071261
DOI: 10.1158/1078-0432.ccr-11-3150

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Research trail→

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Molecular Pathways: Understanding the Role of Rad52 in Homologous Recombination for Therapeutic AdvancementPMID 23071261Read ↗

Reappearance from Obscurity: Mammalian Rad52 in Homologous RecombinationSemantic proximity Read ↗

Emerging Roles of RAD52 in Genome MaintenanceSemantic proximity Read ↗

Homologous recombination in budding yeast expressing the human RAD52 gene reveals a Rad51-independent mechanism of conservative double-strand break repair.Semantic proximity Read ↗

Rad52 inactivation is synthetically lethal with BRCA2 deficiencySemantic proximity Read ↗

RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombinationSemantic proximity Read ↗

Effects of overexpressing wild-type and variant Rad52 on homologous recombination in human cellsSemantic proximity Read ↗

Distinct RAD51 Associations with RAD52 and BCCIP in Response to DNA Damage and Replication StressSemantic proximity Read ↗

Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break RepairSemantic proximity Read ↗

Interaction with Rad51 is indispensable for recombination mediator function of Rad52.Semantic proximity Read ↗

The function of RAD52 N-terminal domain is essential for viability of BRCA-deficient cells.Semantic proximity Read ↗

Regulation and pharmacological targeting of RAD51 in cancerSemantic proximity Read ↗

Mutations altering the DNA binding domains of the human RAD52 protein exert distinct effects on homologous recombination repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

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